synapses was evaluated using SynGO data24; nine genes mapped to SynGO annotations, and genes encoding integral components of the postsynaptic density membrane were borderline significantly enriched (P = 5.43 × 10−3; q-value 0.022; genes PTPRF, SORCS3, and DCC; Supplementary Fig. 5 and Supplementary Table 8). One SynGO-mapped gene was also a part of the upregulated genes during early embryonic brain development (ARHGAP39). Additionally, enrichment of the 76 genes in biological pathways was tested using data from 26 databases implemented in Enrichr25,26. No pathways showed significant enrichment after Bonferroni correction (database significant findings can be found in Supplementary Table 9). Finally, MAGMA27 gene-set analysis using gene-based P-values derived from the full GWAS summary statistics (i.e., no preselection of specific genes) did not reveal any significant findings (top gene sets can be found in Supplementary Table 10).
