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Chunk #32 — Methods — eSNP Analysis

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Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
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Using publically available datasets, we tested for the association of rs1659258 in expression SNPs (eSNP) datasets comprised of the following tissue types: lymphocytes [56], leukocytes [57], leukocytes from patients with Celiac disease [58], lymphoblastoid cell lines (LCL) from children with asthma [59], HapMap LCL from 3 populations [60], a separate study on HapMap CEU LCL [61], peripheral blood monocytes [62], [63], adipose tissue [40], [64], and blood samples [64], 2 studies on brain cortex [62], [65], three large studies of brain regions including prefrontal cortex, visual cortex and cerebellum (Emilsson, personal communication), liver [40], [66], osteoblasts [67], skin [68], and additional fibroblast, T cell and LCL samples [69]. We considered significance to be the association with gene transcript levels as originally described.