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Chunk #7 — METHOD — Statistical Analyses

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Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample.
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Maternal and paternal TS and related diagnoses were examined in relation to offspring diagnoses of OCD and ADHD using logistic regressions with generalized estimating equations (GEE), controlling for the correlation between individuals within families. Parallel logistic regression analyses were also conducted to obtain odds ratios. Gender was included in all analyses as a potential confounder. The percentage of mothers and fathers and the percentage of both parents with TS, CMVT, OCD, OCB, and ADHD were calculated. The presence of nonrandom mating for ADHD and TS or OCD/OCB was assessed by examining the frequency and concordance of maternal/paternal diagnoses of ADHD/ADHD, ADHD/TS or CMVT, and ADHD/OCD or OCB using chi square analyses.