The overarching purpose of this paper is to compare hypothesis-driven candidate genes for schizophrenia from SZGene (Allen et al., 2008) with the largest schizophrenia GWAS published to date (International Schizophrenia Consortium, ISC) (Purcell et al., 2009). First, we characterized the hypothesis-driven candidate gene studies. Second, we conducted quantitative comparisons to determine whether the set of hypothesis-driven candidate genes were either enriched for lower p-values in the ISC results or contained markers with predictive power for schizophrenia. Finally, we performed a qualitative comparison of the most studied hypothesis-driven candidate genes with the ISC results.
