Chunk #52 — DISCUSSION — Absence of change in GluR2/3 immunoreactivity

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Endogenous GluR1-containing AMPA receptors translocate to asymmetric synapses in the lateral amygdala during the early phase of fear memory formation: an electron microscopic immunocytochemical study.

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Because the GluR1-containing AMPARs are likely to also contain GluR2/3 subunits (Greger et al., 2003), it is somewhat surprising that we did not detect a rise in GluR2/3 immunoreactivity, as we did for the GluR1 immunoreactivity. If, as hypothesized above, the GluR1/2 heteromers occur predominantly postsynaptic to the thalamic-plus-cortical axons and these are the predominant pathways undergoing synapse strengthening during the first hour after fear conditioning, then the change occurring at these pathways may have been masked by the GluR2/3-containing AMPARs present at the remaining LA-to-LA synapses.