Finally, recent studies identified a role for CRF2R in the acute locomotor response to methamphetamine, which was associated with CRF2R-dependent neural activation within the central and basolateral amygdala (Giardino et al., 2011b). In contrast, the locomotor effects of cocaine were sensitive to deletion of CRF1R, but not CRF2R (Giardino et al., 2012c). Although EWcp-Ucn1 neurons are transcriptionally activated in response to both amphetamines and cocaine (Spangler et al., 2009), the acute response to methamphetamine is not dampened by genetic deletion of Ucn1, indicating that Ucn2 or Ucn3 is involved in this behavior. Thus, CRF2 receptors may be differentially involved in locomotor effects of different stimulants.
