A SNP at an untranslated region (UTR) of a sequence will be classified as ‘Untranslated’ with no risk. Recently, a new function type ‘3′-UTR post-transcriptional regulation’ was reported (10), but its actual phenotypic risk is still underdetermined. Since we have no substantial evidence about its risk, we will assign such a SNP a moderate-risk ranking. Consequently, our decision tree is complete in the sense that it considers all known functional roles of a SNP in a gene.
