Mouse chromosomal intervals yielding suggestive linkage for an ethanol-induced ataxia phenotype had their human syntenic counterpart identified using data collected and presented by the comparative genomics functions of Ensembl (www.ensembl.org). The proximal- and distal-most markers exhibiting suggestive linkage defined the limits of mouse ethanol ataxia QTL. Using Ensembl’s mouse genome reference NCBIM37, all genes, either wholly or partially within the defined QTL, were identified. Using the Ensembl comparative genomics module, the syntenic human genes (genome reference GRCh37) were identified. Human SNPs were selected for analysis if located within a syntenic gene as defined by its transcript plus 100 kb of flanking sequence. All analyzed genotypes were derived from the Illumina HumanCNV370-Duo DNA Analysis BeadChip.
