events are found (note that the ZNF804A deletion observed in the ISC data set1 is from an individual also included in this study), but in approximately 1700 autism families and 400 unrelated autism cases,31–36 there is a duplication of the entire gene in two affected siblings and a partial ZNF804A duplication in another patient. Because of the incompleteness of the available phenotypic information, drawing strong conclusions about the association of ZNF804A CNVs and mental disorders from the publicly accessible data is difficult. However, considered together with the association between ZNF804A CNVs and psychiatric disorders observed in this report, the existence of two ZNF804A deletion events in controls, several young, and all without detailed phenotype information, and the presence of two ZNF804A duplication events in autism patients, suggests that the link between ZNF804A CNVs and mental disorders should be investigated further.
