Nonetheless, unlike studies of disease traits, which require careful diagnosis and ascertainment, we rapidly obtained a large cohort for which genotype data were available. We replicated a previously identified signal (ADH1C), and identified a novel GWAS signal (near KCNJ9) that has preclinical correlates. Our approach shows that genetic studies of AUDIT in community-based samples are an economical and effective alternative to rigorously diagnosed AUD cohorts that can nevertheless be used to gain insight into the biology of AUD, particularly aspects of alcohol drinking, and comorbid psychopathology.
