To estimate the proportion of the heritability of each transcript that is driven in cis by alleles of high frequency (i.e. common SNPs, here defined as SNPs with minor allele frequency (MAF) > 5%) we combined the results from our heritability and cis-eQTL analyses. As the current sample size is not sufficient to obtain reliable h2 estimates of less than 0.1, we focused on transcripts with h2>0.1 which corresponds to 10,027 (43%), 10,219 (44%) and 7,511 (32%) transcripts in adipose, LCL and skin tissue, respectively (Fig. 1, Supplementary Table 2).
