and other regional effects. Table 2.Detailed information on the functional categories supported by WebGestaltTypeDatabaseMethodNo. of categoriesaNo. of organismsbData sourceGene OntologyBiological processCC24 2788Gene Ontology (http://www.geneontology.org/)Cellular componentCC30798Molecular functionCC95088PathwayKEGGCC3908R package KEGG.dbPathway CommonsCC16511http://www.pathwaycommons.org/pc/WikiPathwaysPC10188http://www.wikipathways.org/index.php/WikiPathwaysNetworkHierarchical protein interaction network moduleCA19932HPRD (http://www.hprd.org/)BioGrid (http://thebiogrid.org/)BOND (http://bond.unleashedinformatics.com/)DIP (http://dip.doe-mbi.ucla.edu/dip/)IntAct (http://www.ebi.ac.uk/intact/)MINT (http://mint.bio.uniroma2.it/mint/)Reactome (http://www.reactome.org/)MicroRNA targetCA8844MSigDB (http://www.broadinstitute.org/gsea/msigdb)Transcription factor targetCA24604MSigDB (http://www.broadinstitute.org/gsea/msigdb)PhenotypePhenotypeCC19 0232Mammalian Phenotype Ontology (http://www.informatics.jax.org)Human Phenotype Ontology (http:www.human-phenotype-ontology.org)Disease and DrugDiseaseCA22861GLAD4U (http://bioinfo.vanderbilt.edu/glad4u)DrugCA7581GLAD4U (http://bioinfo.vanderbilt.edu/glad4u)Chromosomal locationCytogenetic bandCC11 2844Entrez Gene (http://www.ncbi.nlm.nih.gov/gene)aThe number of categories in each database.bThe number of organisms supported by the database.CC, centrally curated; PC, publicly curated; CA, computational analysis.
