After applying QC filters and phenotypic criteria, the Yale-Penn discovery sample included in analyses contained 1,307 AA and 2,340 EA OD cases and 974 AA and 768 EA opioid-exposed controls and 3,554 AA and 2,712 EA CD cases and 478 AA and 915 cocaine-exposed controls. The CATS replication sample contained 1,217 EA OD cases and 88 opioid-exposed controls. Demographic information and mean TD or censoring in the three cohorts are shown in Tables 1 (CD) and 2 (OD). The COGA replication sample included 144 AA and 334 EA OD cases and 354 AA and 1,305 opioid-exposed controls, 572 AA and 759 EA CD cases and 416 AA and 1,620 EA cocaine-exposed controls.
