It is well-known that the gene expression is tissue-specific. In another word, consistent findings between lymphoblastoid cell lines and brain tissues are rare, but inconsistent findings between them are common. Suppose the alcoholism-associated markers have positive cis-eQTL signals in the brain, the chance of these markers happening to have negative cis-eQTL signals (i.e., false negative rate) in the lymphoblastoid cell lines could be common; but the chance of these markers happening to have positive cis-eQTL signals (i.e., false positive rate) in the lymphoblastoid cell lines is rare; and the chance of these markers happening to have distributions highly consistent between cis-eQTL signals in the lymphoblastoid cell lines and gene-disease association signals across different samples should be extremely rare. That is, using lymphoblastoid cell lines for cis-eQTL analysis of brain disorder-related markers might increase the false negative rates due to the relatively poor conservation in cis-eQTLs between cell lines and brain tissue samples, but it should not significantly increase the false positive rates. In the present study, (1) we detected positive cis-eQTL signals in lymphoblastoid cell lines across multiple populations, (2)
