Second, a clear case can be made that COAs are at particular risk for progression along the internalizing pathway toward Negative Affect SUDs. Although we suspect that children who are exposed to both mood disorders and SUDS through their parents (e.g., a parent with depressed, alcoholism or a family with an alcoholic father and depressed/anxious mother) may be especially at risk for progression along the internalizing pathway, we also expect that the processes outlined here may be relevant for understanding the role of affective processes in risk for SUDs in families with an alcoholic parent more generally.
