patterns of association between behavioral stage-based PGS and alcohol milestones, and, reciprocally, between alcohol PGS and stage-based symptom onsets, mirror phenotypic associations would yield important insight into the nature of these relationships. For instance, identifying PGS associations in the context of no symptoms or subthreshold symptoms poorly captured by categorical assessment would highlight the plausibility of shared genetic liability that may not yet be phenotypically expressed at the level of measurement.
