Studies using the B6 and D2 mice have identified QTLs contributing to a variety of alcoholism-related behaviors including alcohol preference, alcohol withdrawal, locomotor activation, and others (Belknap and Atkins 2001; Xu et al. 2002). (For more information on such studies, see the article in this issue by Phillips, pp. 202–207.) Other QTL studies have been conducted in two independently developed rat models of alcohol preference: (1) the alcohol preferring (P) and alcohol nonpreferring (NP) rats and (2) the high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. These analyses have identified additional chromosomal regions that are likely to contain genes influencing alcohol preference.
