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Chunk #29 — Conclusion

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Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: the Nord-Trøndelag Health Study (HUNT).
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In this population-based study on 5531 unselected Norwegian adults no clear association between the Val158Met polymorphism and depression and anxiety was revealed. Among men the Met/Met genotype was associated with lower prevalence of depression when using a high cut-off score, but this may be an incidental finding.