munging pipeline. The summary statistics were then converted into binary format (BESD) to perform the SMR analysis. The scripts used to create the binary (BESD) files for each dataset have been deposited in GitHub. The European subset of ADGC GWAS (phs000372.v1.p1) was used as the LD reference panel to perform the SMR analyses. The analysis was performed using default parameters as listed in the SMR tutorial. The genes below FDR threshold (FDR < 20%; GWAS P < 5 × 10−5; eQTL/mQTL P < 5 × 10−8) and with heterogeneity P value > 0.05 were considered to be causal within each combination of analysis.
