and recruitment of HDACs, co-repressors and other heterochromatin associated proteins (Boyes & Bird, 1991; Klose & Bird, 2006; Nan et al., 1998; Ng et al., 1999). In the CNS, DNA methylation is a critical epigenetic regulator for normal brain development, differentiation and maintenance of function. Dysfunction of the pathways that regulate DNA methylation have been implicated in a variety of brain disorders such as abnormal learning and memory (Feng et al., 2010; Miller & Sweatt, 2007), synaptic plasticity (Chen et al., 2003; Levenson et al., 2006), fragile-x syndrome (Sutcliffe et al., 1992), autism spectrum disorder (Zhubi et al., 2014), Rett’s Syndrome, (an X-linked autism spectrum disorder caused by mutations in methyl-CpG binding protein 2, MeCP2) (Amir et al., 1999), schizophrenia and bipolar disorders (Grayson & Guidotti, 2013).
