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Chunk #19 — Discussion

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Early trauma and increased risk for physical aggression during adulthood: the moderating role of MAOA genotype.
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complicated by the fact that somatic MAOA allele mosaicism, due to X-chromosome inactivation, makes classification of heterozygous females problematic. Previous research has shown that female heterozygotes show patterns of neural activity intermediate between MAOA-L and MAOA-H male hemizygotes and that female homozygotes show patterns of neural activity comparable to male hemizygotes [25]. Because, in our sample physical aggression scores were indistinguishable among the three female genotypes, we were not able to draw conclusions about the status of heterozygous female subjects.