Chunk #12 — Results — Methadone dose genome-wide association study (GWAS) in the Yale-Penn OD sample identifies a significant association upstream of OPRM1 at rs73568641
not deviate from Hardy-Weinberg equilibrium expectiations.43 In AAs, the minor (C) allele of rs73568641 (MAF = 0.1) was associated with a higher daily methadone dose: TT genotype (n = 310), dose mean (SD) = 64.4 mg (29.8 mg); TC genotype (n = 70), dose mean (SD) = 82.3 mg (30.1 mg); CC genotype (n = 3), dose mean (SD) = 108.3 mg (12.6 mg).
