these variants. It is important to note the power calculations we report in our generalization analysis were limited to the effect sizes detected in the original study. These effect sizes could be subject to the “winner’s curse” and may over estimate the true effect size (Xiao & Boehnke 2009; Zhong & Prentice 2010). Using these potentially overestimated effect sizes in our power calculations could consequently over estimate our power to detect these effects.
