On the other hand, when there is a positive incidental finding, the Working Group recommended that laboratories review available literature and databases at the time of the sequence interpretation to insure there is sufficient support for pathogenicity before reporting a variant. The Working Group recognized that there is no single database currently available that represents an accurately curated compendium of known pathogenic variants, nor is there an automated algorithm to identify all novel variants meeting criteria for pathogenicity. Therefore, evaluation and reporting of positive findings in these genes may require significant manual curation.
