The current investigation was designed to address two aims, using data from an all-female twin sample aged 18–27 years. The first was to examine the magnitude of phenotypic associations between childhood maltreatment and two stages of cannabis involvement, initiation and development of cannabis-related problems, in AA and EA women. The second, following up on phenotypic findings, was to estimate the relative influence of additive genetic, shared environmental, and individual-specific environmental factors on childhood maltreatment, cannabis outcomes, and their covariation. The latter aim allowed us to estimate the factors contributing to the well-documented association between childhood maltreatment and cannabis involvement.