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Chunk #20 — Founder populations

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The GenomeAsia 100K Project enables genetic discoveries across Asia.
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Our analysis revealed IBD scores of 1.465 and 0.817 for Finnish and British groups, consistent with previous analyses45. The IBD score of all of the groups was normalized relative to the Finnish group (Fig. 4a and Supplementary Information 12). Our study includes many groups with small population sizes and it is expected that endogamy paired with small population size will greatly increase IBD scores. We found that indigenous and tribal groups had IBD scores that were skewed upwards from non-tribal groups (Fig. 4b). Notably, we found that a number of Asian groups with large urban populations have IBD scores above or close to that of the Finnish population. For example, samples from an outpatient hospital in Chennai, a city with a census size of 9 million, had an IBD score that was approximately 1.3 times greater than the score for the Finnish group.