demonstrated a similar meta-analysis p-value to rs393152 (two-tailed meta-analysis p-value of 1.29 × 10−7, see Supplemental Figure 4) providing further evidence that our AD/PD pleiotropic variant was tagging the MAPT gene and not a false positive result. We also note that rs393152 has been previously shown to tag the H1 haplotype at the MAPT locus (r2 = 0.761). 5 Because of the extensive LD structure in this region, we cannot exclude the possibility that other genes, besides MAPT, are the pathologically relevant genes. However, MAPT is biologically the most plausible candidate.
