Of 47 488 individuals with a cooccurring SUD, 30 767 participants (64.8%) had alcohol use disorder, 26 125 individuals (55.0%) had stimulant use disorder, and 16 913 individuals (35.6%) had sedative use disorder at the start of the first treatment episode (Table 1; eTable 2 in the Supplement). The subcohort used in the within-person (case-crossover) analysis of drug-related poisonings in association with medication treatment periods is described in eTable 2 and eTable 4 in the Supplement; of 12 485 individuals who experienced drug-related poisonings, 10 502 individuals (84.1%) had more than 1 event.