astrocytes (Shaltouki et al., 2013; TCW et al., 2017). Given the reliable platforms for generating human astrocytes from patient derived stem cells, their use in modeling the role of SNPs in ALDH enzymes such as ALDH2 would yield new insight into the effects of alcohol induced toxicity and neuronal dysfunction that may ultimately contribute to the progression of AUDs. Thus, the use of disease relevant cells derived from human stem cells enables the study of multiple aspects of AUD pathophysiology ranging from alcohol concentration, time of alcohol exposure, genetics, environment and alcohol metabolism.
