scale estimate of heritability using [18], and the published disease prevalence in African Americans. In our previous work11, this conversion was not possible because non-randomly ascertained individuals in multiple relatedness classes (e.g. siblings, first cousins, avuncular) were studied, and there is currently no method for accounting for ascertainment in such complex pedigrees. A complete description of the approach, along with an analytical derivation, is given in Online Methods.
