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Chunk #4 — Introduction

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The Genetic Architecture of Obsessive-Compulsive Disorder: Contribution of Liability to OCD From Alleles Across the Frequency Spectrum.
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At the same time, other studies have implicated rare variants in risk for OCD (17–20). Thus, the contribution of inherited genetic variation across the allelic frequency spectrum to the risk of OCD remains uncertain and worthy of further study, as it impacts both our understanding of processes underlying OCD risk architecture and rational study design. Here, using a substantially larger sample compared to previous studies and new genetic data from the Swedish population, we estimate SNP-based heritability for OCD.