common time‐of‐day for alcohol consumption for many, the time course of exposures suggests this was not a significant impediment (Figure 2). Finally, we asked subjects how much they enjoyed controlling their rates of exposure. While this positive valence focus is appropriate for those in an early stage of their drinking career (or within the binge‐intoxication stage of AUD development, summarized in Koob and Volkow 78 ), the instructions may need to be tailored to future populations under study. Despite these limitations, the strengths of this study include obtaining multiple assessments per subject to estimate the pharmacokinetic‐pharmacodynamic relationship, constraining the age ranges in the COGA sample to reduce differences between the samples, and replicating Laboratory interview‐based results in the much larger COGA sample.
