Chunk #26 — Results — Phenome-wide association analyses.

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Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.

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To further explore pleiotropic effects, we performed a series of phenome-wide association studies (PheWAS) of TUD polygenic scores (PGS) in other EHR and clinical cohorts of adults, and a young population-based cohort. We performed these analyses within ancestries.