from posterior to anterior directions (Volpe, 2000; Huppi et al, 2001). By early childhood, most of the axons are myelinated, although myelination continues through adolescence and across the second and third decades of life (Yakovlev 1967; Benes et al. 1994; Blakemore 2012; Lebel et al. 2012). Synaptic proliferation and organization starts at about 20 weeks of gestation, and synapses continue to proliferate from birth to 2 years after birth (Huttenlocher 1979; Huttenlocher and de Courten 1987). However, a regional reorganization occurs most predominantly during childhood and adolescence (Blakemore 2012).
