from family and twin studies [17], [19], [20], [21], [22], [23]–[25], [26], [27], [28], [29], [49] suggesting that there is little, if any, heritability “missing” (i.e., unassayed). While previous TS and OCD GWAS have been underpowered to identify individual susceptibility variants with modest effect sizes, based on these results, future GWAS in much larger samples should identify a large number of true TS and OCD disease variants.
