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Chunk #0 — Introduction

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The genetics of addiction-a translational perspective.
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The term ‘addiction' covers a broad range of maladaptive aspects of drug use or other behaviors leading to clinically significant impairment or distress.1 Addiction includes alcohol use disorders, nicotine dependence, cannabis and cocaine use disorders as well as non-substance–related behaviors. These serious but common psychiatric disorders are among the leading contributors to morbidity and mortality worldwide.2, 3