Pairwise linkage disequilibrium (LD) correlation statistics (r2) were computed using Haploview beta software, version 4.0.10 Multilocus haplotype analyses were performed using HaploStats software,11,12 which estimates haplotype frequencies using an expectation-maximization algorithm in situations in which the haplotype phase is ambiguous. Global and haplotype-specific score statistics and permutation-based P values were calculated after adjustments were made for sex, age, and age2. These analyses did not take into account the relatedness of study subjects.
