To assess the congruence of our results with odds ratios (ORs) for lung cancer reported for rs1051730–rs16969968 genotype (1), data were used from a large case–control study that assessed the relationship between serum cotinine levels and lung cancer (46). This study reported odds ratios and 95% confidence intervals (CIs) for eight separate cotinine intervals with reference to the lowest cotinine range, produced using conditional logistic regression with adjustment for sex, year of birth, time of enrollment, and geographical region, and with adjustment for measurement error using repeated cotinine measurements on a subset of samples. These eight odds ratios and confidence intervals were abstracted, together with the midpoint of each cotinine interval, converted to nmol/L, with the midpoint of the highest interval taken as 400 ng/mL as in the original report. Odds ratios and their confidence intervals were logarithmically transformed so that log odds ratios and their standard errors were calculated. The association between cotinine levels and lung cancer risk is shown in Supplementary Figure 1 (available online). Weighted least squares regression was then carried out on log odds ratios, weighted
