associated with cannabis use (i.e., left hippocampus and bilateral amygdala and ventral striatum) showed no relationship with the SNP. Finally, ever having used cannabis was associated with increased volume in a cluster in the left hippocampus (3.18% greater in ever versus never users; Cohen’s d = 0.39, maximal voxel p-fwe = 0.002; Supplemental Figure S7B). No significant volumetric differences were observed for the right hippocampus, where the SNP exerted main effects, nor was the cluster in the left hippocampus in the same region as the cluster in the right hippocampus to which rs1409568 was associated. Lastly, rs1409568 was not associated with hippocampal volume in an independent large meta-analysis (p=0.33; N=12, 516)(49).
