Kirby et al first suggested that CYP2A5 may modulate hepatic lipid metabolism (Kirby et al., 2011). CYP2A6 upregulation was observed in patients with alcoholic and non-alcoholic fatty liver, and CYP2A6 co-localized with lipid droplets (Niemela et al., 2000). Previously, we reported that CYP2A5 protected against alcoholic liver injury (Hong et al., 2015), but the molecular mechanism for this was not clear. In the present study, we found that alcoholic fatty liver was more pronounced in Cyp2a5−/− mice than in Cyp2a5+/+ mice, and that the alcoholic fatty liver was more pronounced in Pparα−/−/Cyp2a5−/− mice than in Pparα+/+/Cyp2a5−/− mice, suggesting that CYP2A5, together with PPARα, may participate in regulation of lipid metabolism and in the development of alcoholic fatty liver.
