The additional K562 scATAC-seq data have been deposited at GEO with accession number GSE99172. Previously published single cell ATAC-seq data are available from GSE74310 and GSE65360. Bulk hematopeisis ATAC-seq data are available at GSE74912. Macrophage bulk ATAC-seq data was obtained from GSE63341, combinatorial scATAC-seq from GSM1647122, and Roadmap Epigenomics data from the Roadmap Epigenomics Portal (http://egg2.wustl.edu/roadmap/web_portal/).