Chunk #46 — Discussion

Source

Muscarinic type 2 receptors in the lateral dorsal tegmental area modulate cocaine and food seeking behavior in rats.

Embedded

yes

Text

M5R +/- mice were significantly more inefficient than wild type mice in acquiring self-administration behavior, when low doses of cocaine were used. Our study complements this previous work by suggesting a significant role for cholinergic input to VTA dopaminergic neurons during reward seeking behaviors.