Aside from localization of neurons, it has also been demonstrated that with known morphology, it is possible to estimate the ion channel density from extracellular recordings. Gold et al. (2006, 2007) simulated realistic extracellular signals based on adjusting the ion channel distributions in full-compartmental models (see Figure 14). With such a method, the EAP waveforms across the neuron's morphology, measured by multielectrodes, can then be used to constrain compartmental models (Gold et al., 2007). Frey et al. (2009a) used this approach to model a full-compartmental Purkinje neuron using HDMEA recordings, see Figure 10. This shows that using high-density EAP recordings, it is possible to model the ion channel dynamics during neuronal function.
