Recently emergent technologies make it feasible to identify and interrogate the function of noncoding variants at eQTL and ASE loci in human model systems. Human pluripotent stem cells (hPSCs), especially induced pluripotent stem cells (iPSCs), make it possible to generate cohorts of person-specific, renewable, differentiated cell lines in vitro (Zhu et al., 2011). In theory, when drawn from a population with diverse genotypes of common genetic variants, these cohorts might offer the opportunity to validate known eQTL/ASE loci and discover new eQTL/ASE loci “in the dish.” Massively parallel reporter assays (MPRAs) allow investigators to generate high-complexity pools of reporter constructs where each regulatory element or variant of interest is linked to a synthetic reporter gene that carries an identifying barcode (Melnikov et al., 2012; Patwardhan et al., 2012). The reporter construct pools are introduced into cells, and the relative transcriptional activities of the individual elements or variants are measured by sequencing the transcribed reporter mRNAs and counting their specific barcodes. This approach can be used to rapidly profile the regulatory activity of thousands of variants at GWAS loci (Tewhey et
