It should be noted that the transcription of CRHR1 is complex: alternative splicing results in multiple transcript variants, one of which represents a read-through transcript with the neighboring gene MGC57346. A look at the UCSC gene browser (http://genome.ucsc.edu/) shows that haplotype block 1 extends for a great distance proximally and includes MGC57346. Although this gene is of unknown function, our block 1 haplotype association could theoretically result from MGC57346 rather than CRHR1. Finally, the haplotype results did not quite reach the corrected p <0.025 although the SNP results, underlying the haplotype results, were significant.
