Chunk #54 — Methods — Local genetic correlation analyses

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Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.

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Local h2SNP and rg between PTSD and MDD50 were estimated using LAVA53. KGP3 European data were used as the LD reference. Local h2SNP and rg were evaluated across the genome, as partitioned into 2,495 approximately equally sized LD blocks. Local rg was only evaluated for loci where local heritability was significant (P < 0.05/2,495) in both phenotypes. Significance of local rg was based on Bonferroni adjustment for the number of rg evaluated.