At this time, there is a large body of evidence indicating that AUDs are associated with significant changes in the adult human brain, including substantive reductions in WM (e.g., Monnig, Tonigan, Yeo, Thoma, & McCrady, 2013). Despite excitement and interest in how drinking might impact the human adolescent brain, empirical studies remain scarce. Our goal in this systematic review was to offer one of the first syntheses of the human data in this emergent area to determine how active alcohol consumption influences the developing human adolescent brain.