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Chunk #3 — INTRODUCTION

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Stress vulnerability promotes an alcohol-prone phenotype in a preclinical model of sustained depression.
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In the present study, we investigated whether individual variability to the effects of SDPS is associated with subsequent vulnerability to alcohol and whether resilience to the effects of SDPS protects from the development of an addiction prone phenotype in the months following this stressor. In particular, we measured (a) alcohol preference and consumption, (b) motivation for alcohol taking, (c) persistence of alcohol seeking during periods of unavailability, (d) extinction resistance, and finally, (e) reinstatement of alcohol‐seeking behaviors in animals prone to the effects of SPDS and their resilient counterparts.