with the long hypothesized early neurodevelopmental component to this disorder [11, 12]. Although less commonly conceptualized as neurodevelopmental in origin, we observed a similar enrichment of risk variants for bipolar disorder among high confidence fetal brain eQTL. In contrast, we observed no enrichment of risk variants for major depressive disorder, despite similar numbers of tested risk-associated variants at each GWAS P value threshold (Additional file 1: Table S7). Among non-brain traits, the most pronounced enrichment of fetal brain eQTL was observed for variants associated with inflammatory bowel disease (average sevenfold enrichment across the four GWAS P value thresholds), suggesting a developmental component to this condition.
