In order to explore the connection between known height-associated SNPs and teeth phenotypes more deeply, we took 180 robustly associated height variants from the Lango Allen et al. (12) Giant Consortium meta-analysis and examined the degree to which these SNPs were associated with tooth eruption (Supplementary Material, Table S5). Several height-associated SNPs showed strong evidence of association with tooth eruption in the expected direction (i.e. the height increaser allele was associated with faster tooth eruption/more teeth), including rs1351394 in HMGA2 (‘Age at first tooth’: P = 5.3 × 10−7; ‘Number of teeth’: P = 1.0 × 10−9), rs12534093 in IGF2BP3 (‘Age at first tooth’: P = 0.0026; ‘Number of teeth’: P = 2.7 × 10−5), rs1490384 near C6orf173 (‘Age at first tooth’: P = 1.0 × 10−7; ‘Number of teeth’: P = 0.12) and rs1570106 in RAD51L1 (‘Age at first tooth’: P = 0.00012; ‘Number of teeth’: 2.3 × 10−6). Overall, however, the number of height-associated SNPs for which the height increaser allele had a positive effect on faster tooth eruption was not greater than expected by chance (‘Age at
